Shigeyuki Chaki : rechercher sur Z-Library

Michihiko Iijima, Shigeyuki Chaki

Année:

2000

Langue:

english

Fichier:

PDF, 277 KB

english, 2000

Separation-induced ultrasonic vocalization in rat pups: Further pharmacological characterization

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 112 KB

english, 2005

Antipsychotic profile of 5-{2-[4-(6-fluoro-1H-indole-3-yl)piperidin-1-yl]ethyl}-4-(4-fluorophenyl)thiazole-2-carboxylic acid amide (NRA0562) in rats

Kazuaki Takamori, Takeo Funakoshi, Shiho Hirota, Shigeyuki Chaki, Kazuya Kameo

Journal:

Life Sciences

Année:

2002

Langue:

english

Fichier:

PDF, 137 KB

english, 2002

Efficacy of a glycine transporter 1 inhibitor TASP0315003 in animal models of cognitive dysfunction and negative symptoms of schizophrenia

Chaki, Shigeyuki, Shimazaki, Toshiharu, Karasawa, Jun-ichi, Aoki, Takeshi, Kaku, Ayaka, Iijima, Michihiko, Kambe, Daiji, Yamamoto, Shuji, Kawakita, Yasunori, Shibata, Tsuyoshi, Abe, Kumi, Okubo, Taket

Journal:

Taketoshi Okubo, Ryoko Yoshikawa, Shigeyuki Chaki, Shigeru Okuyama, Atsuro Nakazato

Année:

2015

Langue:

english

Fichier:

PDF, 565 KB

english, 2015

[Advances in Pharmacology] || mGlu2/3 receptor as a novel target for rapid acting antidepressants

Chaki, Shigeyuki

Année:

2020

Fichier:

PDF, 434 KB

2020

Design, synthesis and structure–affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands

Journal:

Taketoshi Okubo, Ryoko Yoshikawa, Shigeyuki Chaki, Shigeru Okuyama, Atsuro Nakazato

Année:

2004

Langue:

english

Fichier:

PDF, 557 KB

english, 2004

Design, synthesis, and structure–activity relationships of novel tetracyclic compounds as peripheral benzodiazepine receptor ligands

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 388 KB

english, 2004

Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists

Kosuke Kanuma, Katsunori Omodera, Mariko Nishiguchi, Takeo Funakoshi, Shigeyuki Chaki, Yasuko Nagase, Izumi Iida, Jun-ichi Yamaguchi, Graeme Semple, Thuy-Anh Tran, Yoshinori Sekiguchi

Journal:

Akito Yasuhara, Kazunari Sakagami, Ryoko Yoshikawa, Shigeyuki Chaki, Masato Nakamura, Atsuro Nakazato

Année:

2006

Langue:

english

Fichier:

PDF, 219 KB

english, 2006

Synthesis, in vitro pharmacology, and structure–activity relationships of 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as mGluR2 antagonists

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 379 KB

english, 2006

Prodrugs of 3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (MGS0039): A potent and orally active group II mGluR antagonist with antidepressant-like potential

Akito Yasuhara, Masato Nakamura, Kazunari Sakagami, Toshiharu Shimazaki, Ryoko Yoshikawa, Shigeyuki Chaki, Hiroshi Ohta, Atsuro Nakazato

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 279 KB

english, 2006

Structure–activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor

Dai Nozawa, Taketoshi Okubo, Takaaki Ishii, Hiroyuki Kakinuma, Shigeyuki Chaki, Shigeru Okuyama, Atsuro Nakazato

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 308 KB

english, 2007

Novel piperazines: Potent melanocortin-4 receptor antagonists with anxiolytic-like activity

Dai Nozawa, Taketoshi Okubo, Takaaki Ishii, Kazuaki Takamori, Shigeyuki Chaki, Shigeru Okuyama, Atsuro Nakazato

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 238 KB

english, 2007

Synthesis, in vitro pharmacology, and pharmacokinetic profiles of 2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-1-fluorocyclopropanecarboxylic acid and its 6-heptyl ester, a potent mGluR2 antagonist

Kazunari Sakagami, Akito Yasuhara, Shigeyuki Chaki, Ryoko Yoshikawa, Yasunori Kawakita, Akio Saito, Takeo Taguchi, Atsuro Nakazato

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 389 KB

english, 2008

Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1

Kosuke Kanuma, Katsunori Omodera, Mariko Nishiguchi, Takeo Funakoshi, Shigeyuki Chaki, Graeme Semple, Thuy-Anh Tran, Bryan Kramer, Debbie Hsu, Martin Casper, Bill Thomsen, Nigel Beeley, Yoshinori Seki

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 117 KB

english, 2005

Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1

Kosuke Kanuma, Katsunori Omodera, Mariko Nishiguchi, Takeo Funakoshi, Shigeyuki Chaki, Graeme Semple, Thuy-Anh Tran, Bryan Kramer, Debbie Hsu, Martin Casper, Bill Thomsen, Yoshinori Sekiguchi

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 155 KB

english, 2005

Synthesis and structure–affinity relationships of 4-(5-Aryl-1,2,3,6-tetrahydropyridino)pyrimidine derivatives as corticotropin-releasing factor1 receptor antagonists

Toshihito Kumagai, Taketoshi Okubo, Hiromi Kataoka-Okubo, Shigeyuki Chaki, Shigeru Okuyama, Atsuro Nakazato

Journal:

Atsuro Nakazato, Yoshinori Sekiguchi, Kohmei Ohta, Shigeyuki Chaki, Shigeru Okuyama

Année:

2001

Langue:

english

Fichier:

PDF, 156 KB

english, 2001

Chemical modification of apomorphine to discover σ ligands: 6H-dibenzo[b,d]pyran and carbazole analogues

Journal:

Journal of Neurochemistry

Année:

1999

Langue:

english

Fichier:

PDF, 204 KB

english, 1999

Polyamine transport, accumulation, and release in brain

Takashi Masuko, Kuniko Kusama-Eguchi, Kaori Sakata, Tadashi Kusama, Shigeyuki Chaki, Shigeru Okuyama, Keith Williams, Keiko Kashiwagi, Kazuei Igarashi

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 355 KB

english, 2003

An mGluR2/3 antagonist, MGS0039, exerts antidepressant and anxiolytic effects in behavioral models in rats

Takao Yoshimizu, Toshiharu Shimazaki, Akie Ito, Shigeyuki Chaki

Journal:

Michihiko Iijima, Toshiharu Shimazaki, Akie Ito, Shigeyuki Chaki

Année:

2006

Langue:

english

Fichier:

PDF, 186 KB

english, 2006

Effects of metabotropic glutamate 2/3 receptor antagonists in the stress-induced hyperthermia test in singly housed mice

Journal:

Toshiharu Shimazaki, Ayaka Kaku, Shigeyuki Chaki

Année:

2007

Langue:

english

Fichier:

PDF, 437 KB

english, 2007

d-Serine and a glycine transporter-1 inhibitor enhance social memory in rats

Journal:

Agnieszka Pałucha-Poniewiera, Joanna M. Wierońska, Piotr Brański, Katarzyna Stachowicz, Shigeyuki Chaki, Andrzej Pilc

Année:

2010

Langue:

english

Fichier:

PDF, 180 KB

english, 2010

On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 648 KB

english, 2010

Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission

Yukio Ago, Ryota Araki, Koji Yano, Naoki Hiramatsu, Toshiyuki Kawasaki, Shigeyuki Chaki, Atsuro Nakazato, Hirotaka Onoe, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda

Journal:

Toshihito Kumagai, Taketoshi Okubo, Hiromi Kataoka-Okubo, Shigeyuki Chaki, Shigeru Okuyama, Atsuro Nakazato

Année:

2011

Langue:

english

Fichier:

PDF, 248 KB

english, 2011

Chemical modification of aryl-1,2,3,6-tetrahydropyridinopyrimidine derivative to discover corticotropin-releasing factor1 receptor antagonists: Aryl-1,2,3,6-tetrahydropyridino-purine, -3H-1,2,3-triazolo[4,5-d]pyrimidine, -purin-8-one, and -7H-pyrrolo[2,3-d]pyrimidine derivatives

Journal:

Shigeyuki Chaki, Atsuro Nakazato, Shigeru Okuyama

Année:

2001

Langue:

english

Fichier:

PDF, 160 KB

english, 2001

Atypical Antipsychotic Profile of NRA0045, a Novel Dopamine D4 receptor, 5-Hydroxytryptamine2A (5-HT2A) Receptor and α1 Adrenoceptor Antagonist

Journal:

CNS Drug Reviews

Année:

2000

Langue:

english

Fichier:

PDF, 239 KB

english, 2000

Neuropharmacological Profile of an Atypical Antipsychotic, NRA0562

Shiho Hirota, Naoya Kawashima, Shigeyuki Chaki, Shigeru Okuyama

Journal:

CNS Drug Reviews

Année:

2003

Langue:

english

Fichier:

PDF, 155 KB

english, 2003

ATC0175: An Orally Active Melanin-Concentrating Hormone Receptor 1 Antagonist for the Potential Treatment of Depression and Anxiety

Shigeyuki Chaki, Jun-ichi Yamaguchi, Hisaharu Yamada, William Thomsen, Thuy-Anh Tran, Graeme Semple, Yoshinori Sekiguchi

Journal:

CNS Drug Reviews

Année:

2005

Langue:

english

Fichier:

PDF, 120 KB

english, 2005

Role of carboxyl tail of the rat angiotensin II type 1A receptor in agonist-induced internalization of the receptor

Chaki, Shigeyuki, Guo, Deng-Fu, Yamano, Yoshiaki, Ohyama, Kenji, Tani, Makio, Mizukoshi, Masato, Shirai, Heigorou, Inagami, Tadashi

Journal:

Kidney International

Année:

1994

Langue:

english

Fichier:

PDF, 402 KB

english, 1994

The atypical antipsychotic profile of NRA0045, a novel dopamine D4 and 5-hydroxytryptamine2A receptor antagonist, in rats

Shigeru Okuyama, Shigeyuki Chaki, Naoya Kawashima, Yoshiko Suzuki, Shin-ichi Ogawa, Toshihito Kumagai, Atsuro Nakazato, Masashi Nagamine, Kazumasa Yamaguchi, Kazuyuki Tomisawa

Journal:

British Journal of Pharmacology

Année:

1997

Langue:

english

Fichier:

PDF, 394 KB

english, 1997

A newly found angiotensin II receptor subtype mediates cyclic GMP formation in differentiated Neuro-2A cells

Shigeyuki Chaki, Tadashi Inagami

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Année:

1992

Langue:

english

Fichier:

PDF, 144 KB

english, 1992

Mood disorders: Regulation by metabotropic glutamate receptors

Andrzej Pilc, Shigeyuki Chaki, Gabriel Nowak, Jeffrey M. Witkin

Journal:

Biochemical Pharmacology

Année:

2008

Langue:

english

Fichier:

PDF, 320 KB

english, 2008

AMPA receptor stimulation mediates the antidepressant-like effect of a group II metabotropic glutamate receptor antagonist

Jun-ichi Karasawa, Toshiharu Shimazaki, Naoya Kawashima, Shigeyuki Chaki

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 287 KB

english, 2005

Effects of quercetin on the sleep–wake cycle in rats: Involvement of gamma-aminobutyric acid receptor type A in regulation of rapid eye movement sleep

Daiji Kambe, Makiko Kotani, Makoto Yoshimoto, Shinsuke Kaku, Shigeyuki Chaki, Kazuki Honda

Journal:

Michihiko Iijima, Akie Ito, Shinsuke Kurosu, Shigeyuki Chaki

Année:

2010

Langue:

english

Fichier:

PDF, 305 KB

english, 2010

Pharmacological characterization of repeated corticosterone injection-induced depression model in rats

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 504 KB

english, 2010

Anxiolytic- and antidepressant-like profile of a new CRF1 receptor antagonist, R278995/CRA0450

Shigeyuki Chaki, Atsuro Nakazato, Ludo Kennis, Masato Nakamura, Claire Mackie, Masayuki Sugiura, Petra Vinken, David Ashton, Xavier Langlois, Thomas Steckler

Journal:

Toshiharu Shimazaki, Michihiko Iijima, Shigeyuki Chaki

Année:

2004

Langue:

english

Fichier:

PDF, 814 KB

english, 2004

Anxiolytic-like activity of MGS0039, a potent group II metabotropic glutamate receptor antagonist, in a marble-burying behavior test

Journal:

Toshiharu Shimazaki, Michihiko Iijima, Shigeyuki Chaki

Année:

2004

Langue:

english

Fichier:

PDF, 205 KB

english, 2004

The pituitary mediates the anxiolytic-like effects of the vasopressin V1B receptor antagonist, SSR149415, in a social interaction test in rats

Journal:

Toshiharu Shimazaki, Ayaka Kaku, Shigeyuki Chaki

Année:

2006

Langue:

english

Fichier:

PDF, 147 KB

english, 2006

Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via the AMPA receptor in rats

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 169 KB

english, 2007

Group II metabotropic glutamate receptor agonists as a potential drug for schizophrenia

Shigeyuki Chaki

Journal:

Abdallah Ahnaou, Thomas Steckler, Annick Heylen, Ludo Kennis, Atsuro Nakazato, Shigeyuki Chaki, Wilhelmus H.I.M. Drinkenburg

Année:

2010

Langue:

english

Fichier:

PDF, 446 KB

english, 2010

R278995/CRA0450, a corticotropin-releasing factor (CRF1) receptor antagonist modulates REM sleep measures in rats: Implication for therapeutic indication

Journal:

Toshiharu Shimazaki, Shigeyuki Chaki

Année:

2012

Langue:

english

Fichier:

PDF, 1.34 MB

english, 2012

Anxiolytic-like effect of a selective and non-peptidergic melanocortin 4 receptor antagonist, MCL0129, in a social interaction test

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 124 KB

english, 2005

MCL0042: A nonpeptidic MC4 receptor antagonist and serotonin reuptake inhibitor with anxiolytic- and antidepressant-like activity

Shigeyuki Chaki, Yuichi Oshida, Shin-ichi Ogawa, Takeo Funakoshi, Toshiharu Shimazaki, Taketoshi Okubo, Atsuro Nakazato, Shigeru Okuyama

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 124 KB

english, 2005

In vitro and antinociceptive profile of HON0001, an orally active NMDA receptor NR2B subunit antagonist

Sayoko Suetake-Koga, Toshiharu Shimazaki, Kazuaki Takamori, Shigeyuki Chaki, Kosuke Kanuma, Yoshinori Sekiguchi, Tsutomu Suzuki, Toyohiko Kikuchi, Yoshimitsu Matsui, Toshio Honda

Journal:

Shigeru Okuyama, Takashi Sakagawa, Shigeyuki Chaki, Yasuko Imagawa, Toshihiro Ichiki, Tadashi Inagami

Année:

2006

Langue:

english

Fichier:

PDF, 157 KB

english, 2006

Anxiety-like behavior in mice lacking the angiotensin II type-2 receptor

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 383 KB

english, 1999

Neuropharmacological profiles of a novel atypical antipsychotic, NRA0562, in rats

Naoya Kawashima, Takeo Funakoshi, Tomohiro Omura, Shigeyuki Chaki, Kazuya Kameo, Shigeru Okuyama

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 338 KB

english, 2001

Corrigendum to “Neuropharmacological profiles of a novel atypical antipsychotic, NRA0562, in rats” [Eur. J. Pharmacol. 423 (2001) 27–33]

Naoya Kawashima, Takeo Funakoshi, Tomohiro Omura, Shigeyuki Chaki, Kazuya Kameo, Shigeru Okuyama

Journal:

Shigeyuki Chaki, Naoya Kawashima, Yoshiko Suzuki, Toshiharu Shimazaki, Shigeru Okuyama

Année:

2001

Langue:

english

Fichier:

PDF, 87 KB

english, 2001

Cocaine- and amphetamine-regulated transcript peptide produces anxiety-like behavior in rodents

Journal:

Shigeyuki Chaki, Shin-ichi Ogawa, Yoshihisa Toda, Takeo Funakoshi, Shigeru Okuyama

Année:

2003

Langue:

english

Fichier:

PDF, 243 KB

english, 2003

Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents

Journal: